SLDB

Speech/Language Disorders Database

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Specific Language Impairment

The following data points are curated from the literature, and indicate differences between subjects with Specific Language Impairment and control subjects. Coordinates are in MNI space, and brain labels are as delineated in the text. Click on any column to sort by that column.

Imaging Phenotype XYZ Region Name Effect Description Article Year
Gray matter morphometry differences - - - inferior frontal gyrus SLI patients showed a mean rightward asymmetry in volume of Broca's area whereas normal language controls showed a mean leftward asymmetry De Fossé et al 2004
BOLD activation differences during Switch Task for Children 27 58 -5 superior orbitofrontal lobe,  BA 11 SLI patients showed increased activation relative to controls during non-switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -3 31 53 BA 8,  superior medial frontal lobe SLI patients showed increased activation relative to controls during non-switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -50 11 34 precentral gyrus,  BA 44 SLI patients showed increased activation relative to controls during non-switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -39 -7 18 Rolandic operculum,  BA 48 SLI patients showed increased activation relative to controls during non-switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -26 -71 51 BA 7,  superior parietal lobe SLI patients showed increased activation relative to controls during non-switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -28 -7 11 putamen SLI patients showed increased activation relative to controls during non-switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -30 -92 -1 BA 18,  medial occipital lobe SLI patients showed increased activation relative to controls during non-switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 14 -94 19 BA 17,  superior occipital lobe SLI patients showed increased activation relative to controls during non-switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 21 17 -15 BA 11,  inferior orbitofrontal lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -18 36 -14 BA 11,  medial orbitofrontal lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 18 63 5 BA 10,  superior frontal lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 21 31 28 BA 9,  superior frontal lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 27 63 10 BA 10,  superior frontal lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 12 68 13 BA 10,  medial frontal lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 29 50 4 BA 10,  medial frontal lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -12 44 21 BA 10,  medial frontal lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -42 28 43 BA 44,  medial frontal lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 47 26 28 BA 44,  inferior frontal lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -51 16 7 BA 48,  frontal inferior operculum SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 32 -16 46 BA 6,  precentral gyrus SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -50 5 26 BA 6,  left precentral gyrus SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 52 6 34 postcentral gyrus,  BA 4 SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 47 -20 33 postcentral gyrus,  BA 38 SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -56 -1 18 postcentral gyrus,  BA 48 SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 10 14 49 BA 6,  supplementary motor area SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 56 -42 16 BA 42,  superior temporal lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -54 -34 -2 BA 21,  medial temporal lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -20 -63 50 BA 7,  superior parietal lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -9 -29 33 BA 32,  cingulum SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -11 28 25 BA 32,  cingulum SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 12 15 34 BA 32,  cingulum SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 16 48 13 BA 32,  cingulum SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 33 -25 13 Heschl's gyrus,  BA 48 SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 31 -17 17 insula,  BA 48 SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -19 18 1 putamen SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 21 8 -1 putamen SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 16 9 16 caudate nucleus SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children -19 -80 38 BA 19,  superior occipital lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during Switch Task for Children 18 -82 38 BA 19,  superior occipital lobe SLI patients showed increased activation relative to controls during the switch condition of the Switch Task for Children Dibbets et al 2006
BOLD activation differences during word recognition - - - inferior frontal gyrus SLI patients showed hypoactivation of the insular portion of the inferior frontal gyrus during the word recognition component of a verbal working memory task Ellis Weismer et al 2005
BOLD activation differences during sentence encoding - - - parietal region SLI patients showed hypoactivation of the left parietal region attention areas compared to control subjects during the sentence encoding portion of a verbal working memory task Ellis Weismer et al 2005
BOLD activation differences during sentence encoding - - - precentral sulcus SLI patients showed hypoactivation of the central sulcus bilaterally compared to control subjects during the sentence encoding portion of a verbal working memory task Ellis Weismer et al 2005
Gray matter morphometry differences - - - angular gyrus Children with developmental language disorder showed a loss of rightward asymmetry in gray matter volume of the angular gyrus (AG) compared to controls (no comparable effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - posterior inferior temporal gyrus Children with developmental language disorder showed a gain of leftward asymmetry in gray matter volume of the posterior inferior temporal gyrus (T3p) compared to controls (no comparable effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - temporal pole Children with developmental language disorder showed a gain of leftward asymmetry in gray matter volume of the temporal pole (TP) compared to controls (no comparable effect was found in a high functioning autism group) Herbert et al 2005
Gray matter morphometry differences - - - posterior temporal fusiform Children with developmental language disorder showed a gain of rightward asymmetry in gray matter volume of the posterior temporal fusiform cortex (TFp) compared to controls (no comparable effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - planum polare Children with developmental language disorder showed a gain of rightward asymmetry in gray matter volume of the planum polare (PP) compared to controls (no comparable effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - frontal operculum Children with developmental language disorder showed a loss of leftward asymmetry in gray matter volume of the frontal operculum (FO) compared to controls (the same effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - inferior frontal gyrus pars triangularis Children with developmental language disorder showed a loss of leftward asymmetry in gray matter volume of the pars triangularis (F3t) compared to controls (the same effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - postcentral gyrus Children with developmental language disorder showed a loss of leftward asymmetry in gray matter volume of the postcentral gyrus (POG) compared to controls (the same effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - cuneal cortex Children with developmental language disorder showed a loss of rightward asymmetry in gray matter volume of the cuneal cortex (CN) compared to controls (the same effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - supracalcarine gyurs Children with developmental language disorder showed a loss of rightward asymmetry in gray matter volume of the supracalcarine gyrus (SCLC) compared to controls (the same effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - planum temporale Children with developmental language disorder showed a gain of leftward asymmetry in gray matter volume of the planum temporale (PT) compared to controls (the same effect was found in a non-autism developmental language disorder group) Herbert et al 2005
Gray matter morphometry differences - - - anterior supramarginal gyrus Children with developmental language disorder showed a gain of leftward asymmetry in gray matter volume of the anterior supramarginal gyrus (Sga) compared to controls (the same effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - inferior temporo-occipital gyrus Children with developmental language disorder showed a gain of rightward asymmetry in gray matter volume of the inferior temporo-occipital gyrus (TO3) compared to controls (the same effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - temporo-occipital fusiform gyrus Children with developmental language disorder showed a gain of rightward asymmetry in gray matter volume of the tempero-occipital fusiform gyrus (TOF) compared to controls (the same effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - frontal pole Children with developmental language disorder showed a gain of rightward asymmetry in gray matter volume of the frontal pole (FP) compared to controls (the same effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - anterior parahippocampal gyrus Children with developmental language disorder showed a gain of rightward asymmetry in gray matter volume of the anterior parahippocampal gyrus (Pha) compared to controls (the same effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - posterior supramarginal gyrus Children with developmental language disorder showed a gain of rightward asymmetry in gray matter volume of the posterior supramarginal gyrus (SGp) compared to controls (the same effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - precuneus Children with developmental language disorder showed a gain of rightward asymmetry in gray matter volume of the precuneus (PCN) compared to controls (the same effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - lingual gyrus Children with developmental language disorder showed a gain of rightward asymmetry in gray matter volume of the lingual gyrus (LG) compared to controls (the same effect was found in an autism group) Herbert et al 2005
Gray matter morphometry differences - - - caudate nucleus Gray matter volume increase in younger children with SLI compared with control subjects Soriano-Mas et al 2009
Gray matter morphometry differences - - - entorhinal area,  BA 28/34 Gray matter volume increase in younger children with SLI compared with control subjects Soriano-Mas et al 2009
Gray matter morphometry differences - - - entorhinal area,  BA 28/34 Gray matter volume increase in younger children with SLI compared with control subjects Soriano-Mas et al 2009
Gray matter morphometry differences - - - perisylvian region,  BA 22 Gray matter volume increase in all children with SLI compared with control subjects Soriano-Mas et al 2009
White matter morphometry differences - - - medial frontal cortex, juxtacortical white matter White matter volume increase in younger children with SLI compared with control subjects Soriano-Mas et al 2009
Gray matter morphometry differences - - - middle occipital gyrus Gray matter volume increase in all children with SLI compared with control subjects Soriano-Mas et al 2009
White matter morphometry differences - - - middle temporal gyrus, white matter White matter volume increase in younger children with SLI compared with control subjects Soriano-Mas et al 2009
White matter morphometry differences - - - middle temporal gyrus, white matter White matter volume increase in younger children with SLI compared with control subjects Soriano-Mas et al 2009
Gray matter morphometry differences - - - middle occipital gyrus, medial Gray matter volume increase in younger children with SLI compared with control subjects Soriano-Mas et al 2009
Gray matter morphometry differences - - - BA 4,  motor cortex Gray matter volume increase in younger children with SLI compared with control subjects Soriano-Mas et al 2009
Gray matter morphometry differences - - - BA 7,  precuneus Gray matter volume increase in younger children with SLI compared with control subjects Soriano-Mas et al 2009
Gray matter morphometry differences - - - BA 38,  temporopolar cortex Gray matter volume increase in younger children with SLI compared with control subjects Soriano-Mas et al 2009
Gray matter morphometry differences - - - gray matter Children with SLI showed larger gray matter volumes than controls Soriano-Mas et al 2009
White matter morphometry differences - - - white matter Children with SLI showed larger white matter volumes than controls Soriano-Mas et al 2009